𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Partial linkage map of chromosome 13q in the region of the Wilson disease and retinoblastoma genes

✍ Scribed by Jonathan L. Haines; Laurie Ozelius; Peter St George-Hyslop; Nancy S. Wexler; James F. Gusella; P. Michael Conneally; G. P. Vogler

Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
345 KB
Volume
5
Category
Article
ISSN
0741-0395

No coin nor oath required. For personal study only.

✦ Synopsis

Genetic linkage maps are useful tools for defining the location of disease genes. Previously published maps of human chromosome 13 have been incomplete and have had ambiguities of order in the vicinity of the Wilson disease (WND) and retinoblastoma (RB1) genes. We have defined a six-locus map of this region using a large reference pedigree from Venezuela. Our map provides landmarks which will aid in the localization of WND, in determining the extent of deletions in retinoblastoma, and in the mapping of other marker loci.

πŸ“œ SIMILAR VOLUMES

Two distinct commonly deleted regions on
Two distinct commonly deleted regions on chromosome 13q suggest involvement of BRCA2 and retinoblastoma genes in sporadic breast carcinomas
✍ Kazuhiro Tsukamoto; Noriko Ito; Masataka Yoshimoto; Takuji Iwase; Takashi Tada; πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 561 KB

## BACKGROUND. Frequent allelic losses on the long arm of chromosome 13 in sporadic breast carcinomas suggest that a tumor suppressor gene(s) on 13q is involved in this type of carcinoma. The presence of a familial breast carcinoma susceptibility gene, BRCA2, and the retinoblastoma susceptibility

Expression of EVI1 and the retinoblastom
Expression of EVI1 and the retinoblastoma genes in acute myelogenous leukemia with t(3;13)(q26;q13–14)
✍ Yufu, Yuji; Sadamura, S.; Ishikura, H.; Abe, Y.; Katsuno, M.; Nishimura, J.; Naw πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 726 KB

The EVll DNA-binding protein gene on chromosome 3q26 has been reported to be activated in some leukemia cells with alterations in 3q26. We present an acute myelogenous leukemia (AML) patient with a rare chromosomal translocation, t(3;13)(q26.2;q13-14). By reverse transcription-polymerase chain react

Physical mapping of the chromosome 7 bre
Physical mapping of the chromosome 7 breakpoint region in an SLOS patient with t(7;20) (q32.1;q13.2)
✍ Alley, Tiffany L.; Scherer, Stephen W.; Huizenga, Jack J.; Tsui, Lap-Chee; Walla πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 104 KB πŸ‘ 2 views

## Smith -Lemli-Opitz syndrome (SLOS) is an autosomal recessive disorder characterized by multiple congenital anomalies and mental retardation. SLOS has an associated defect in cholesterol biosynthesis, but the molecular genetic basis of this condition has not yet been elucidated. Previously our g