Two distinct commonly deleted regions on chromosome 13q suggest involvement of BRCA2 and retinoblastoma genes in sporadic breast carcinomas
✍ Scribed by Kazuhiro Tsukamoto; Noriko Ito; Masataka Yoshimoto; Takuji Iwase; Takashi Tada; Fujio Kasumi; Yusuke Nakamura; Mitsuru Emi
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 561 KB
- Volume
- 78
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
BACKGROUND.
Frequent allelic losses on the long arm of chromosome 13 in sporadic breast carcinomas suggest that a tumor suppressor gene(s) on 13q is involved in this type of carcinoma. The presence of a familial breast carcinoma susceptibility gene, BRCA2, and the retinoblastoma susceptibility gene (RB) on the same chromosomal arm implies that one or the other, or both, of these genes may be critically affected by those allelic losses.
METHODS.
To investigate the possible involvement of BRCA2 and RB in sporadic breast carcinomas, the authors examined allelic losses in 246 breast carcinomas with 14 polymorphic microsatellite markers on 13q12-qI4.