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Partial duplications of the MSH2 and MLH1 genes in hereditary nonpolyposis colorectal cancer

✍ Scribed by Baert-Desurmont, Stephanie; Buisine, Marie-Pierre; Bessenay, Emilie; Frerot, Stephanie; Lovecchio, Tonio; Martin, Cosette; Olschwang, Sylviane; Wang, Qing; Frebourg, Thierry

Book ID
110026866
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
165 KB
Volume
15
Category
Article
ISSN
1018-4813

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Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are pred