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Partial duplication of the MLL gene in acute myelogenous leukemia without karyotypic aberration

✍ Scribed by Y.L. Kwong


Book ID
114136171
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
409 KB
Volume
97
Category
Article
ISSN
0165-4608

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## Background. Recently, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in 20% of adult cases of acute myelogenous leukemia (AML), and this length abnormality was suggested to be associated with leukemic progression. Procedure. We examined the mRNA expression of the FLT3 gene

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## Abstract The formation of a leukemogenic fusion product in hematopoietic malignancies is commonly achieved by chromosomal translocation. Alternate and cytogenetically undetectable mechanisms of fusion transcript generation have been documented for __BCR__–__AB1__, __AML1__–__ETO__, __PML__–__RAR