Partial duplication of the MLL gene in acute myelogenous leukemia without karyotypic aberration
β Scribed by Y.L. Kwong
- Book ID
- 114136171
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 409 KB
- Volume
- 97
- Category
- Article
- ISSN
- 0165-4608
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## Background. Recently, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in 20% of adult cases of acute myelogenous leukemia (AML), and this length abnormality was suggested to be associated with leukemic progression. Procedure. We examined the mRNA expression of the FLT3 gene
## Abstract The formation of a leukemogenic fusion product in hematopoietic malignancies is commonly achieved by chromosomal translocation. Alternate and cytogenetically undetectable mechanisms of fusion transcript generation have been documented for __BCR__β__AB1__, __AML1__β__ETO__, __PML__β__RAR