A partial nontandem duplication of the MLL gene in four patients with acute myeloid leukemia
✍ Scribed by Iveta Šárová; Jana Březinová; Zuzana Zemanová; Libuše Lizcová; Adéla Berková; Silvia Izáková; Eva Malinová; Ota Fuchs; Arnošt Kostečka; Dana Provazníková; Jitka Filkuková; Jacqueline Maaloufová; Jan Starý; Kyra Michalová
- Book ID
- 113513584
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 704 KB
- Volume
- 195
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Partial tandem duplication (PTD) of the __MLL__ gene and internal tandem duplication (ITD) of the juxtamembrane region of the __FLT3__ receptor tyrosine kinase gene have been described in acute myeloid leukemia (AML) patients, preferentially in those with normal cytogenetics. These alte
## Abstract Tandem duplication (TD) of the __MLL__ or __FLT3__ gene in acute myeloid leukemia (AML) has been reported. We examined whether TD of these two genes occurs simultaneously. We analyzed 13 AML and 2 myelodysplastic syndrome patients, including 6 adult patients with trisomy 11 and 9 pediat