Partial correction of chromosome instability in Fanconi anemia by desferrioxamine
β Scribed by B. Porfirio; G. Ambroso; G. Giannella; G. Isacchi; B. Dallapiccola
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 326 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The distribution of chromosome breaks induced by the antitumor drug cis-diamine-dichloroplatinum (II) in lymphocyte cultures from Fanconi anemia patients was analyzed. Breakpoints occurred nonrandomly over an arbitrarily defined human karyotype of 319 bands. These bands were classified according to
## Abstract ## Background Adenoβassociated virus (AAV) vectors have been shown to correct a variety of mutations in human cells by homologous recombination (HR) at high rates, which can overcome insertional mutagenesis and transgene silencing, two of the major hurdles in conventional gene addition