𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Partial correction of chromosome instability in Fanconi anemia by desferrioxamine

✍ Scribed by Martin Foot; Holger Hoehn

Publisher
Springer
Year
1990
Tongue
English
Weight
109 KB
Volume
84
Category
Article
ISSN
0340-6717

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Fragile sites and chromosome instability
Fragile sites and chromosome instability: the distribution of breaks induced bycis-diamine-clichloro-platinum (II) in Fanconi anemia lymphocyte cultures
✍ B. Porfirio; D. Smeets; L. Beckers; D. Caporossi; B. Tedeschi; P. Vernole; H. Jo πŸ“‚ Article πŸ“… 1991 πŸ› Springer 🌐 English βš– 457 KB

The distribution of chromosome breaks induced by the antitumor drug cis-diamine-dichloroplatinum (II) in lymphocyte cultures from Fanconi anemia patients was analyzed. Breakpoints occurred nonrandomly over an arbitrarily defined human karyotype of 319 bands. These bands were classified according to

Correction of mutant Fanconi anemia gene
Correction of mutant Fanconi anemia gene by homologous recombination in human hematopoietic cells using adeno-associated virus vector
✍ Kittiphong Paiboonsukwong; Fumi Ohbayashi; Haruka Shiiba; Emi Aizawa; Takayuki Y πŸ“‚ Article πŸ“… 2009 πŸ› John Wiley and Sons 🌐 English βš– 288 KB

## Abstract ## Background Adeno‐associated virus (AAV) vectors have been shown to correct a variety of mutations in human cells by homologous recombination (HR) at high rates, which can overcome insertional mutagenesis and transgene silencing, two of the major hurdles in conventional gene addition