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Partial Asymmetric Synthesis in the Darzens Reaction

โœ Scribed by SISIDO, KEIITI; NAKANISI, OSAMU; NOZAKI, HITOSI


Book ID
127350960
Publisher
American Chemical Society
Year
1961
Tongue
English
Weight
512 KB
Volume
26
Category
Article
ISSN
0022-3263

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Asymmetric synthesis of ฮฑ,ฮฒ-epoxysulfone
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Enantioselective synthesis of ct, l~-epoxysulfones by the Darzens reaction was achieved under phase-transfer catalyzed conditions. The reaction of chloromethyl phenylsulfone with various aromatic aldehydes smoothly proceeded in the presence of a catalytic amount (10 mol %) of chiral quaternary ammon