Asymmetric Synthesis of Arylalanines via Asymmetric Aza-Darzens (ADZ) Reaction.
✍ Scribed by Naomi E. Maguire; Andrew B. McLaren; J. B. Sweeney
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 135 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The domino Mannich/aza‐Michael reaction of γ‐malonate‐substituted α,β‐unsaturated esters with __N__‐protected arylaldimines has been achieved. Catalyzed by bifunctional thioureas, 2,5‐__cis__‐configured polysubstituted pyrrolidines are obtained in good to excellent yields (76–99%), enan