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[Part 1: Biological Sciences] || 5α -cholest-8(14)-en-3β -ol-15-one, a Potent Inhibitor of Sterol Biosynthesis, Lowers Serum Cholesterol and Alters Distribution of Cholesterol in Lipoproteins in Baboons

✍ Scribed by George J. Schroepfer, Edward J. Parish, Alemka Kisic, Evelyn M. Jackson, Cynthia Mersinger Farley and Glen E. Mott

Book ID: 123623341
Publisher: National Academy of Sciences
Year: 1982
Tongue: English
Weight: 768 KB
Volume: 79
Category: Article
ISSN: 0027-8424
DOI: 10.2307/11761

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📜 SIMILAR VOLUMES

[Part 1: Biological Sciences] || Correct

[Part 1: Biological Sciences] || Correction: 5a-Cholest-8(14)-en-3/3-ol-15-one, A Potent Inhibitor of Sterol Biosynthesis, Lowers Serum Cholesterol and Alters Distribution of Cholesterol in Lipoproteins in Baboons

📂 Article 📅 1982 🏛 National Academy of Sciences 🌐 English ⚖ 176 KB

[Part 1: Biological Sciences] || 5α -Cho

[Part 1: Biological Sciences] || 5α -Cholest-8(14)-en-3β -ol-15-one Lowers Serum Cholesterol and Induces Profound Changes in the Levels of Lipoprotein Cholesterol and Apoproteins in Monkeys Fed a Diet of Moderate Cholesterol Content

✍ George J. Schroepfer, Bette C. Sherrill, Ker-Shi Wang, William K. Wilson, Alemka 📂 Article 📅 1984 🏛 National Academy of Sciences 🌐 English ⚖ 956 KB

Inhibition of hepatic sterol synthesis a

Inhibition of hepatic sterol synthesis and reduction of serum cholesterol in rats by 5α-cholest-8(14)-en-3β-ol-15-one

✍ Dwight L. Raulston; Clifford O. Mishaw; Edward J. Parish; George J. Schroepfer J 📂 Article 📅 1976 🏛 Elsevier Science 🌐 English ⚖ 267 KB

Inhibitors of sterol synthesis. Effects

Inhibitors of sterol synthesis. Effects of dietary 5α-cholest-8(14)-en-eβ-ol-15-one on early enzymes in hepatic cholesterol biosynthesis

✍ Larry R. Miller; Dwight L. Raulston; George J. Schroepfer Jr. 📂 Article 📅 1988 🏛 Elsevier Science 🌐 English ⚖ 704 KB

The effects of dietary administration (0.1070 in diet for 8 days) of 5t~-cholest-8( )-en-3/I-ol-15-one on the levels of activity of cytosolic acetoacetyl coenzyme A thiolase, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, and microsomal HMG-CoA reductase in liver have been studied in male

Inhibitors of sterol synthesis. Dietary

Inhibitors of sterol synthesis. Dietary administration of 5α-cholest-8(14)-en-3β-ol-15-one inhibits the intestinal absorption of cholesterol in lymph-cannulated rats

✍ George J. Schroepfer Jr.; Armand Christophe; Dolores H. Needleman; Alemka Kisic; 📂 Article 📅 1987 🏛 Elsevier Science 🌐 English ⚖ 333 KB

Inhibitors of sterol synthesis. Chemical

Inhibitors of sterol synthesis. Chemical synthesis and spectral properties of (25R)-5α-cholest-8(14)-ene-3β,15β,26-triol, a potential metabolite of 3β-hydroxy-5α-cholest-8(14)-en-15-one and its effects on 3-hydroxy-3-methylglutaryl-coenzyme A reductase in CHO-K1 cells

✍ Shankar Swaminathan; Frederick D. Pinkerton; William K. Wilson; George J. Schroe 📂 Article 📅 1992 🏛 Elsevier Science 🌐 English ⚖ 570 KB

(25R)-5 alpha-Cholest-8(14)-ene-3 beta,15 beta,26-triol (III) was prepared by reduction of (25R)-3 beta,26-diacetoxy-5 alpha-cholest-8(14)-en-15-one with sodium borohydride followed by treatment of the crude product with lithium aluminium hydride. The trihydroxysterol III, a potential metabolite of