p53 modulation of the DNA damage respons
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E. Scott Helton; Xinbin Chen
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Article
📅
2007
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John Wiley and Sons
🌐
English
⚖ 338 KB
## Abstract The tumor suppressor p53 plays a central role in the DNA damage response. After exposure to genotoxic stress, p53 can both positively and negatively regulate cell fate. Initially, p53 promotes cell survival by inducing cell cycle arrest, DNA repair, and other pro‐survival pathways. Howe