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Parkin as a tumor suppressor gene for hepatocellular carcinoma

✍ Scribed by Fujiwara, M; Marusawa, H; Wang, H-Q; Iwai, A; Ikeuchi, K; Imai, Y; Kataoka, A; Nukina, N; Takahashi, R; Chiba, T

Book ID: 109970521
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 353 KB
Volume: 27
Category: Article
ISSN: 0950-9232
DOI: 10.1038/onc.2008.199

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## Abstract The __Parkin__ gene is an extremely large gene (1.5 Mb) within the highly unstable FRA6E common fragile site (CFS) region, which is frequently altered in ovarian, breast, and hepatocellular carcinomas. Because __Parkin__/FRA6E has genomic similarities to __FHIT__/FRA3B and __WWOX__/FRA1

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BACKGROUND. Specific mutations of the p53 tumor suppressor gene in hepatocellular carcinoma (HCC) have been reported from several parts of the world, but to the authors' knowledge to date the status of this gene has not been studied in HCC patients in India, where HCC is one of the major cancers and