EMP3 as a tumor suppressor gene for esophageal squamous cell carcinoma
β Scribed by Shoichi Fumoto; Keiko Hiyama; Keiji Tanimoto; Takuya Noguchi; Jun Hihara; Eiso Hiyama; Tsuyoshi Noguchi; Masahiko Nishiyama
- Book ID
- 116334963
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 330 KB
- Volume
- 274
- Category
- Article
- ISSN
- 0304-3835
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## Abstract We analyzed the mutational and methylation status of the __spleen tyrosine kinase__ (__Syk__) gene and both mRNA and protein levels in primary oral squamous cell carcinoma (OSCC) and OSCCβderived cell lines and examined the function of the __Syk__ gene in OSCCβderived cell lines __in vi
Loss of heterozygosity at 4 tumor-suppressor gene loci (pS3, apc, mcc and Rb) was investigated using polymerase chain reactions, in 49 esophageal squamous-cell carcinoma specimens from patients who had undergone curative resection. Mutations in the p53 gene within exons 5 to 8 were also examined. LO