Suppressor of cytokine signaling 1, a newly proposed tumor suppressor gene associated with hepatocellular carcinoma
โ Scribed by Kazuyoshi Ohkawa
- Publisher
- Springer Japan
- Year
- 2004
- Tongue
- English
- Weight
- 113 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0944-1174
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## Background: Frequent allelic losses on the short arm of chromosome 8 in several types of human cancers, and deletion maps of this region in tumor dnas, have suggested that 8p harbors one or more genes that are important for suppressing tumorigenesis in the tissues in question. ## Methods: To d
The tumor suppressor gene CDKN2A (MTS1/p16), located on chromosome 9p21, is inactivated in a variety of tumors including melanomas and tumors of the biliary tract, pancreas, and stomach. The aim of the present study was to determine whether this gene is inactivated in hepatocellular carcinoma (HCC).
To identify the location of one or more putative tumor suppressor genes that may be involved in urinary bladder cancer, we examined 82 such tumors for allelic losses at 19 microsatellite loci on 8p. Loss of heterozygosity was observed in 31 of the cases. Deletion mapping identified a commonly delete