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Parathyroid hormone sensitizes long bones to the stimulation of bone resorption by 1,25-dihydroxyvitamin D3

✍ Scribed by Dr. J. P. T. M. van Leeuwen; J. C. Birkenhäger; M. P. Bos; G. J. C. M. van der Bemd; M. P. M. Herrmann-Erlee; H. A. P. Pols

Book ID
112118898
Publisher
American Society for Bone and Mineral Research
Year
2009
Tongue
English
Weight
758 KB
Volume
7
Category
Article
ISSN
0884-0431

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The cytokine interleukin-6 (IL-6) was produced by neonatal mouse parietal bones during a 6- or 48-hour culture period in response to prostaglandin E2 (PGE2) and bovine parathyroid hormone (PTH) 1-34 fragment but not 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. At the same time there was an increase in ta