Prolonged and ubiquitous inhibition by interferon γ of bone resorption induced by parathyroid hormone-related protein, 1,25-dihydroxyvitamin D3, and interleukin 1 in fetal mouse forearm bones

Interleukin-6 does not mediate the stimu

Interleukin-6 does not mediate the stimulation by prostaglandin E2, parathyroid hormone, or 1,25 dihydroxyvitamin D3of osteoclast differentiation and bone resorption in neonatal mouse parietal bones

✍ I. Holt; M. W. J. Davie; I. P. Braidman; M. J. Marshall 📂 Article 📅 1994 🏛 Springer 🌐 English ⚖ 633 KB

The cytokine interleukin-6 (IL-6) was produced by neonatal mouse parietal bones during a 6- or 48-hour culture period in response to prostaglandin E2 (PGE2) and bovine parathyroid hormone (PTH) 1-34 fragment but not 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. At the same time there was an increase in ta