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Paraoxonase polymorphisms PON1 192 and 55 and longevity in Italian centenarians and Irish nonagenarians. A pooled analysis

✍ Scribed by Irene M Rea; Pascal P McKeown; Dorothy McMaster; Ian S Young; Chris Patterson; Maurice J Savage; Christine Belton; Francesca Marchegiani; Fabiola Olivieri; Massimiliano Bonafe; Claudio Franceschi

Book ID
113614413
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
123 KB
Volume
39
Category
Article
ISSN
0531-5565

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## Abstract Paraoxonase 1 (PON 1) is a high‐density lipoprotein (HDL)‐associated enzyme with antioxidant function protecting low‐density lipoprotein (LDL) from oxidation. PON 1 has two amino acid polymorphisms in coding region; L/M 55 and Q/R 192. These polymorphisms modulate paraoxonase activity o