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Lack of an association between Paraoxonase 1 gene polymorphisms (Q192R, L55M) and Alzheimer's disease: A meta-analysis

✍ Scribed by Yan Pi; Lili Zhang; Kai Chang; Binghu Li; Lu Guo; Chuanqin Fang; Changyue Gao; Jingzhou Wang; Jing Xiang; Jingcheng Li

Book ID: 118488073
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 669 KB
Volume: 523
Category: Article
ISSN: 0304-3940
DOI: 10.1016/j.neulet.2012.06.071

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## Abstract Paraoxonase 1 (PON 1) is a high‐density lipoprotein (HDL)‐associated enzyme with antioxidant function protecting low‐density lipoprotein (LDL) from oxidation. PON 1 has two amino acid polymorphisms in coding region; L/M 55 and Q/R 192. These polymorphisms modulate paraoxonase activity o