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Paraoxonase 1 Met–Leu 54 polymorphism is associated with Parkinson’s disease

✍ Scribed by Sofya N Akhmedova; Andrey K Yakimovsky; Eugene I Schwartz


Book ID
119465317
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
134 KB
Volume
184
Category
Article
ISSN
0022-510X

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✍ Andrea Carmine; Silvia Buervenich; Olof Sydow; Maria Anvret; Lars Olson 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 54 KB 👁 1 views

Paraoxonase1 (PON1) is an arylesterase mainly expressed in the liver that hydrolyzes organophosphates such as pesticides, reported risk factors for Parkinson's disease (PD), and other neurotoxins. A Leu-Met 54 polymorphism in the gene for PON1-affecting enzyme activity was recently shown, employing