We derived three parametric survival models (the log-normal, log logit, and Weibull) from the clinical data of chemotherapy trials for stage II breast cancer. We then used these models to generate simulated survival data, which we analysed using both parametric (log-normal) and non-parametric (logra
Parametric modelling of cost data: some simulation evidence
โ Scribed by Andrew Briggs; Richard Nixon; Simon Dixon; Simon Thompson
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 117 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1057-9230
- DOI
- 10.1002/hec.941
No coin nor oath required. For personal study only.
โฆ Synopsis
Recently, commentators have suggested that the distributional form of cost data should be explicitly modelled to gain efficiency in estimating the population mean. We perform a series of simulation experiments to evaluate the usual sample mean and the mean estimator of a lognormal distribution, in the context of both theoretical distributions and three large empirical datasets. The sample mean is always unbiased, but is somewhat less efficient when the population distribution is truly lognormal. However the lognormal estimator can perform appallingly when the true distribution is not lognormal. In practical situations, where the true distribution is unknown, the sample mean generally remains the estimator of choice, especially when limited sample size prohibits detailed modelling of the cost data distribution.
๐ SIMILAR VOLUMES
## Abstract Suicide rates for adolescents have doubled since 1970 and tripled since 1960, even as rates for other age groups have declined. Using a Beckerโtype model of household production and consumption, we demonstrate conditions under which utility maximizing parents allocate time away from tim
Three approaches to modelling spatial data in which simulation plays a vital role are described and illustrated with examples. The ยฎrst approach uses ยฏexible regression models, such as generalized additive models, together with locational covariates to ยฎt a surface to spatial data. We show how the b
A nonparametric method for linkage analysis has been developed and applied to the Problem 1 data set of the Genetic Analysis Workshop 9. Basically, the univariate matched pair strategy of the transmission disequilibrium test has been adapted to multivariate modeling using the conditional logistic fu
The statistic of interest in most health economic evaluations is the incremental cost-e!ectiveness ratio. Since the variance of a ratio estimator is intractable, the health economics literature has suggested a number of alternative approaches to estimating con"dence intervals for the cost-e!ectivene