This paper presents a novel guided search strategy Extremal Optimization (EO) with constrained structure for protein folding. In the proposed algorithm, evaluating the fitness of each monomer in an amino-acid sequence is introduced to guide the improvement of the conformation. In addition, a constra
Parameter optimization for the Gaussian model of protein folding
β Scribed by Albert Erkip; Burak Erman; Chaok Seok; Ken Dill
- Book ID
- 108366475
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 1005 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0032-3861
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The role of local interactions in protein folding has recently been the subject of some controversy. Here we investigate an extension of Zwanzig's simple and general model of folding in which local and nonlocal interactions are represented by functions of single and multiple conformational degrees o
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## Abstract The cluster model of protein folding [Kanehisa, M. I. & Tsong, T. Y. (1978) __J. Mol. Biol.__ **124**, 177β194] is further investigated for the thermodynamic and kinetic properties of protein foldingβunfolding transitions. A cluster is a locally formed ordered region in the polypeptide