This paper presents a novel guided search strategy Extremal Optimization (EO) with constrained structure for protein folding. In the proposed algorithm, evaluating the fitness of each monomer in an amino-acid sequence is introduced to guide the improvement of the conformation. In addition, a constra
On the optimal folding of protein molecules
โ Scribed by Namiot, V. A. ;Batyanovskii, A. V. ;Filatov, I. V. ;Tumanyan, V. G. ;Esipova, N. G.
- Book ID
- 110157445
- Publisher
- Biophysical Society of Japan
- Year
- 2011
- Tongue
- English
- Weight
- 176 KB
- Volume
- 56
- Category
- Article
- ISSN
- 1349-2942
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
The role of local interactions in protein folding has recently been the subject of some controversy. Here we investigate an extension of Zwanzig's simple and general model of folding in which local and nonlocal interactions are represented by functions of single and multiple conformational degrees o
## Abstract We offer simple solutions to three kinematic problems that occur in the folding of proteins. We show how to construct suitably local elementary Monte Carlo moves, how to close a loop, and how to fold a loop without breaking the bond that closes it. ยฉ 2003 Wiley Periodicals, Inc. J Compu
## Abstract The failure to appreciate that the hydration of polar groups is a major contribution to the entropy of protein unfolding has led to considerable underestimates for the loss of configurational freedom when a protein chain folds.