✦ LIBER ✦

On the entropy of protein folding

✍ Scribed by George I. Makhatadze; Peter L. Privalov

Publisher: Cold Spring Harbor Laboratory Press
Year: 2008
Tongue: English
Weight: 484 KB
Volume: 5
Category: Article
ISSN: 0961-8368
DOI: 10.1002/pro.5560050312

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✦ Synopsis

Abstract

The failure to appreciate that the hydration of polar groups is a major contribution to the entropy of protein unfolding has led to considerable underestimates for the loss of configurational freedom when a protein chain folds.

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