Palladium mediated total synthesis of o-acetylphenylacetic acids: a general route to indolo[2,3-b]naphthalene-6,11-diones
✍ Scribed by Jacobo Cruces; Juan C Estévez; Luis Castedo; Ramón J Estévez
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 81 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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## Abstract For Abstract see ChemInform Abstract in Full Text.
We describe here a new, efficient general synthesis of o-acetylbenzoic acids by Heck palladium-catalyzed arylation of n-butyl vinyl ether with o-bromobenzoic acid esters and the use of these compounds as starting materials for the synthesis of 3-benzylideneisochroman-1,4-diones, which readily rearra
## Abstract For Abstract see ChemInform Abstract in Full Text.
We describe a new total synthesis of 2-styrylbenzoic acids by Heck coupling of methyl o-iodobenzoates to styrenes. Additionally, in the first general synthesis of naphtho[2,1-f ]isoquinolines, these acids were transformed into phenanthrenoic acids and thence into the target compounds by a six-step s