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Palladium-mediated total synthesis of 2-styrylbenzoic acids: a general route to 2-azachrysenes

✍ Scribed by Carme Pampı́n; Juan C Estévez; Luis Castedo; Ramón J Estévez

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
138 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

We describe a new total synthesis of 2-styrylbenzoic acids by Heck coupling of methyl o-iodobenzoates to styrenes. Additionally, in the first general synthesis of naphtho[2,1-f ]isoquinolines, these acids were transformed into phenanthrenoic acids and thence into the target compounds by a six-step sequence including a Bischler-Napieralski cyclization.

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