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Palladium-catalyzed synthesis of quinolines from allylic alcohols and o-iodoaniline

✍ Scribed by Richard C. Larock; Mann-Yan Kuo


Publisher
Elsevier Science
Year
1991
Tongue
French
Weight
237 KB
Volume
32
Category
Article
ISSN
0040-4039

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## Abstract Treatment of allylic alcohols containing a 1,1‐disubstituted alkene with a palladium catalyst and hydrogen gas (1β€…bar) results in facile isomerization to their corresponding trisubstituted (__E__)‐allylic alcohols, along with small amounts of the corresponding hydrogenated products.

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Ally1 diethyl phosphates (\_1) can be easily substituted with malonates and amines in the presence of palladium(O) catalyst. Synthetic utility of the reaction is demonstrated by the sequential amination-amination and alkylation-amination of (Z)-4-acetoxybut-2-enyl diethyl phosphate Cl,b) with high r