𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Palladium(O)-catalyzed allylic alkylation and amination of allylic phosphates

✍ Scribed by Yoshio Tanigawa; Kazuaki Nishimura; Akihiko Kawasaki; Shun-Ichi Murahashi

Publisher
Elsevier Science
Year
1982
Tongue
French
Weight
237 KB
Volume
23
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Ally1 diethyl phosphates (_1) can be easily substituted with malonates and amines in the presence of palladium(O) catalyst. Synthetic utility of the reaction is demonstrated by the sequential amination-amination and alkylation-amination of (Z)-4-acetoxybut-2-enyl diethyl phosphate Cl,b) with high regio-and stereoselectivity. Allylic transformations catalyzed by palladium are of great value, since an allylic moiety is important for organic synthesis 2 . The most common and

πŸ“œ SIMILAR VOLUMES

Palladium-Catalyzed Asymmetric Allylic A
Palladium-Catalyzed Asymmetric Allylic Alkylation of Ketone Enolates.
✍ Barry M. Trost; Gretchen M. Schroeder πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons βš– 54 KB πŸ‘ 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.

Palladium-Catalyzed Asymmetric Allylic A
Palladium-Catalyzed Asymmetric Allylic Alkylation of Ketone Enolates
✍ Barry M. Trost; Gretchen M. Schroeder πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 390 KB πŸ‘ 2 views

## Abstract Palladium‐catalyzed asymmetric allylic alkylation of nonstabilized ketone enolates to generate quaternary centers has been achieved in excellent yield and enantioselectivity. Optimized conditions consist of performing the reaction in the presence of two equivalents of LDA as base, one e