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Palladium-Catalyzed Asymmetric Addition of Pronucleophiles to Allenes

✍ Scribed by Trost, Barry M.; Jäkel, Christoph; Plietker, Bernd


Book ID
127077445
Publisher
American Chemical Society
Year
2003
Tongue
English
Weight
39 KB
Volume
125
Category
Article
ISSN
0002-7863

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Palladium catalyzed addition of certain carbon pronucleophiles 2 to conjugated enynes l afforded the corresponding allenes 3 in good to excellent yields. The most reactive methynes such o.~ methylmalononitrile 2e enabled to undezgo double addition leading to alkenes 4. Catalyst optimization supporte