The in situ prepared three-component system Pd(OAc) 2 -1,3-dialkylbenzimidazolium chlorides (2a-f) and Cs 2 CO 3 catalyses, quantitatively, the Suzuki cross-coupling of deactivated aryl chlorides and Heck coupling reactions of aryl bromide and iodide substrates. The 1,3-dialkylbenzimidazolium salts
Palladium-catalysed symmetrical and unsymmetrical coupling of aryl halides
✍ Scribed by Jwanro Hassan; Christel Gozzi; Marc Lemaire
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 209 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1387-1609
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📜 SIMILAR VOLUMES
Palladium-catalysed cross-coupling of 2-trimethylsilylpyridine with aryl halides in the presence of stoichiometric silver(I) oxide, and catalytic TBAF allows the rapid preparation of the corresponding pyridin-2-ylaryl compounds in moderate to good yields under mild thermal conditions.
Unsymmetrical biaryls bearing electron-donating and electron-withdrawing functional groups have been obtained in an efficient manner by Pd-catalyzed coupling of aryl halides. Aryl bromides react with aryl iodides to yield unsymmetrical biaryls with marked selectivity.
## Abstract Aryl bromides containing a (1,4,5,6‐tetrahydro‐6‐oxopyridin‐3‐yl)methyl substituent can be coupled with aryl halides yielding unsummetrical biaryls. In the course of this process, the cyclic enamide is oxidized to the 2(1__H__)‐pyridinone. The reaction proceeds by a six‐membered pallada