p75 neurotrophin receptor and fenretinide-induced signaling in neuroblastoma
β Scribed by Ganeshan, Veena R.; Schor, Nina F.
- Book ID
- 121560480
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 883 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0344-5704
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## Abstract To understand the functional interactions between the TrkA and p75 nerve growth factor (NGF) receptors, we stably transfected LAN5 neuroblastoma cells with an expression vector for ETβR, a chimeric receptor with the extracellular domain of the epidermal growth factor receptor (EGFR), an
The recent recognition that the p75 neurotrophin receptor, p75 NTR , can induce apoptotic signals has contributed to the perception that it acts primarily as a death receptor. Although the molecular mechanisms of p75 NTR signaling remain to be fully characterized, many of the currently identified pa