✦ LIBER ✦

NGF induces apoptosis in a human neuroblastoma cell line expressing the neurotrophin receptor p75NTR

✍ Scribed by P. Kuner; C. Hertel

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 162 KB
Volume: 54
Category: Article
ISSN: 0360-4012
DOI: 10.1002/(sici)1097-4547(19981115)54:4<465::aid-jnr4>3.0.co;2-t

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✦ Synopsis

Nerve growth factor (NGF) has been demonstrated to support survival and differentiation of neuronal cells. Recently, a role of NGF in neuronal apoptosis has been suggested. NGF binds to tropomyosin receptor kinase A (TrkA) and to 75-kDa NGF receptor (p75 NTR ). TrkA is responsible for differentiation and survival, but p75 NTR , a member of the death receptor family, seems to mediate the apoptotic effect of NGF. Here we demonstrate that NGF-but not neurotrophin-3 (NT-3) or brain-derived neurotrophic factor (BDNF)induced apoptosis in p75 NTR -expressing human neuroblastoma SK-N-MC cells. BDNF prevented NGFinduced apoptosis. NGF-induced apoptosis was accompanied by the release of NFB p65 and the activation of stress-activated protein kinase/c-jun amino terminal kinase. Because p75 NTR and NGF are upregulated in Alzheimer's disease, NGF/p75 NTR might be involved in neuronal cell death related to the disease.

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