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p75 Neurotrophin receptor signaling : Mechanisms for neurotrophic modulation of cell stress?

✍ Scribed by Rick T. Dobrowsky; Bruce D. Carter

Publisher: John Wiley and Sons
Year: 2000
Tongue: English
Weight: 88 KB
Volume: 61
Category: Article
ISSN: 0360-4012
DOI: 10.1002/1097-4547(20000801)61:3<237::aid-jnr1>3.0.co;2-m

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✦ Synopsis

The recent recognition that the p75 neurotrophin receptor, p75 NTR , can induce apoptotic signals has contributed to the perception that it acts primarily as a death receptor. Although the molecular mechanisms of p75 NTR signaling remain to be fully characterized, many of the currently identified pathways activated by p75 NTR may be generally characterized as stress response signals. This review describes recent advances in identifying the molecular components involved in p75 NTR signal transduction and suggests that p75 NTR signaling may more aptly serve as a general mechanism for the transduction and modulation of stress signals.

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