P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63?
✍ Scribed by Faridoni-Laurens, Laetitia; Bosq, Jacques; Janot, François; Vayssade, Muriel; Le Bihan, Marie-Luce; Kaghad, Mourad; Caput, Daniel; Bénard, Jean; Ahomadegbe, Jean-Charles
- Book ID
- 110065935
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 956 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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Mutation of the p53 tumor suppressor gene has been demonstrated in a large proportion of human head and neck squamous cell carcinomas (HNSCCs) and has been assumed to play a role in the pathogenesis of these tumors, although no formal evidence of functional aberration has been demonstrated. In this
## Abstract ## Objectives This study aims at investigating the prognostic values of serum p53 protein and anti‐p53 antibody in patients undergoing surgical treatment for head and neck squamous cell carcinoma (HNSCC). ## Methods Serum p53 protein and anti‐p53 antibody concentrations were determin