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p53 Restoration Leads to Tumor Senescence and Regression: Implications for Cancer Therapy

โœ Scribed by Andrew W. Tai; Raymond T. Chung

Book ID
119759950
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
69 KB
Volume
133
Category
Article
ISSN
0016-5085

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## Abstract ## Background. In the majority of human cancers, the tumor suppressor activity of p53 is impaired because of mutational events or interactions with other proteins (ie, MDM2). The loss of p53 function is responsible for increased aggressiveness of cancers, while tumor chemoresistance an