A Senescence Program Controlled by p53 and p16INK4a Contributes to the Outcome of Cancer Therapy
โ Scribed by Clemens A. Schmitt; Jordan S. Fridman; Meng Yang; Soyoung Lee; Eugene Baranov; Robert M. Hoffman; Scott W. Lowe
- Book ID
- 117269120
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 526 KB
- Volume
- 109
- Category
- Article
- ISSN
- 0092-8674
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Primary cultured mouse hepatic cells become senescent within a short period, although rare cells form colonies from which continuously proliferating cell lines can be established. In contrast, hepatic tumor (HT) cells show little senescence and higher colony-forming capacity. To assess this differen