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p53 protein overexpression and chemosensitivity in breast cancer

✍ Scribed by Andreas Makris; TrevorJ. Powles; Mitch Dowsett; Craig Allred; Marie-Christine Mathieu; Serge Koscielny; Marie-Luce Le Bihan; Marc Spielmann; Rodrigo Arriagada; Institut Gustave-Roussy breast cancer group

Book ID
118558047
Publisher
The Lancet
Year
1995
Tongue
English
Weight
310 KB
Volume
345
Category
Article
ISSN
0140-6736

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πŸ“œ SIMILAR VOLUMES

Human breast cancer: frequent p53 allele
Human breast cancer: frequent p53 allele loss and protein overexpression
✍ S. Singh; M. Simon; I. Meybohm; I. Jantke; W. Jonat; H. Maass; H. W. Goedde πŸ“‚ Article πŸ“… 1993 πŸ› Springer 🌐 English βš– 786 KB

A sample of 114 primary breast tumors and corresponding constitutional DNA were tested for loss of heterozygosity (LOH) of the YNZ22 and p53 genes, both located in the 17p13 region. Loss of the p53 allele was found in 28 of 44 primary breast carcinomas (64%). In contrast LOH in only 26 of 61 tumors