p53 mutations and overexpressions in Japanese breast cancer
โ Scribed by Toshihiko Fukushima; Masamitsu Onda; Rikiya Abe; Tohru Otake; Izo Kimijima; Atsuo Tsuchiya
- Book ID
- 117569303
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 748 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0748-7983
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๐ SIMILAR VOLUMES
## Abstract Focal adhesion kinase (FAK) is overexpressed in a number of tumors, including breast cancer. Another marker of breast cancer tumorigenesis is the tumor suppressor gene __p53__ that is frequently mutated in breast cancer. In the present study, our aim was to find a correlation between FA
A sample of 114 primary breast tumors and corresponding constitutional DNA were tested for loss of heterozygosity (LOH) of the YNZ22 and p53 genes, both located in the 17p13 region. Loss of the p53 allele was found in 28 of 44 primary breast carcinomas (64%). In contrast LOH in only 26 of 61 tumors