p53 mutations, O6-alkylguanine DNA alkyltransferase activity, and sensitivity to procarbazine in human brain tumors
β Scribed by Russell, Susan J.; Ye, Yun-Wei; Waber, Pamela G.; Shuford, Matthew; Schold, S. Clifford; Nisen, Perry D.
- Book ID
- 120568060
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 373 KB
- Volume
- 75
- Category
- Article
- ISSN
- 0008-543X
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## Abstract The DNA repair enzyme O^6^βmethylguanineβDNA methyltransferase (MGMT) removes alkylating adducts from the O^6^ position of guanine and protects cells from cytotoxic and mutagenic effects. Expression of __MGMT__ is decreased in some cancers, which may be the result of methylation of CpG
The DNA repair protein O 6 -methylguanine-DNA methyltransferase (MGMT) is a main determinant of resistance of cells to the cytostatic effects of O 6 -alkylguanine-generating alkylating agents. The purpose of our study was to assay MGMT activity in cells of lung cancers and to correlate MGMT levels w