## Abstract __O__^6^βAlkylguanineβDNA alkyltransferase (ATase) activity was determined in crude sonicates of tissues obtained from the F2 offspring of human ATase transgenic founder mice. In certain cases, samples were analyzed both before and after administration of zinc sulfate in the drinking wa
β¦ LIBER β¦
Depletion of O6-alkylguanine-DNA alkyltransferase activity in mammalian tissues and human tumor xenografts in nude mice by treatment with O6-methylguanine
β Scribed by M. Eileen Dolan; Gregory L. Larkin; Hugh F. English; Anthony E. Pegg
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 653 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0344-5704
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O 6 -Alkylguanine-DNA-alkyltransferase (ATase) is an important modulator of alkylating agent-induced toxicity and carcinogenicity, but those factors which influence the expression of this repair protein in human tissues are poorly characterised. In this study, we have determined ATase levels in macr