Validated markers are needed to identify operable lung cancer patients with poor prognosis. About one-half of nonsmall-cell lung cancers (NSCLCs) carry a mutation in the p53 tumor-suppressor gene. We examined 101 NSCLC patients for surgical stage, completeness of resection, tobacco smoking, asbestos
p53 Mutations in non-small-cell lung cancers occurring in individuals without a past history of active smoking
โ Scribed by Takagi, Y; Osada, H; Kuroishi, T; Mitsudomi, T; Kondo, M; Niimi, T; Saji, S; Gazdar, AF; Takahashi, T; Minna, JD
- Book ID
- 109837518
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 839 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0007-0920
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## Abstract Our previous study showed a characteristic p53 mutational spectrum in lung tumors from lung cancer patients in the Western Pennsylvania region. To further understand the involvement of p53 mutations in lung tumor development, in this study we compared p53 mutational spectra and distribu
FIGURE 1 -Survival after surgery of patients with NSCLC according to p53 expression level. Log-rank tests used for comparisons.
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