Mutations in exon 7 and 8 of p53 as poor prognostic factors in patients with non-small cell lung cancer
β Scribed by Huang, Cheng-long; Taki, Toshihiko; Adachi, Masashi; Konishi, Takaaki; Higashiyama, Masahiko; Miyake, Masayuki
- Book ID
- 110061296
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 357 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0950-9232
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Our previous study showed a characteristic p53 mutational spectrum in lung tumors from lung cancer patients in the Western Pennsylvania region. To further understand the involvement of p53 mutations in lung tumor development, in this study we compared p53 mutational spectra and distribu
p53 tumour suppressor gene alterations are one of the most frequent genetic events in lung cancer. A subset of patients with p53 mutation and cancer exhibited circulating serum anti-p53 self-antibodies (p53-Ab). The prevalence of these antibodies in lung cancer is currently being analysed in a multi
Accumulation of mutant p53 protein occurs frequently in human malignancies, including 40-60% of non-small cell lung carcinomas. The implications of such p53 over-expression, usually assessed by immunohistochemical techniques, for the prognosis of lung cancer patients remain undetermined. In this stu