We examined loss of heterozygosity (LOH) at the retinoblastoma susceptibility gene (RB1) locus on chromosome 13q14 in 20 non-small-cell lung cancers (NSCLCs) using polymorphic markers. The expression of RB protein was examined by immunohistochemical analysis of paraffinembedded specimens of the same
Deletion and mutation of WWOX exons 6–8 in human non-small cell lung cancer
✍ Scribed by Zhou Yulong; Xu Yongjian; Zhang Zhenxiang
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- Chinese
- Weight
- 510 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0510-9752
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract To identify tumor‐suppressor genes on chromosome 10 in non‐small cell lung cancers, we isolated 10 types of splicing variant of the __HELLS/SMARCA6__ gene transcripts. HELLS/SMARCA6 is a novel member of SNF2 family, which is implicated in cellular functions like chromatin remodeling. Va
Previously we have reported non-random cytogenetic abnormalities involving the short arm of chromosome 9 (9p) in the majority of primary non-small cell lung cancer (NSCLC) patient samples, which indicated loss of DNA sequences. In another lung tumor, pleural malignant mesothelioma (MM), cytogenetic
Frequent losses of heterozygosity observed at several chromosomal loci in primary lung cancers have indicated the existence of several tumor suppressor genes associated with this type of cancer. We have examined loss of heterozygosity on chromosomal arm 8p in 49 cases of non-small cell lung carcinom
## Abstract Identification of a homozygous deletion in cancer cells provides strong evidence for the location of a tumor suppressor gene (TSG). We analyzed the 2p24 homozygous deletion of a non‐small‐cell lung cancer (NSCLC) cell line, NCI‐H2882, and found that the deletion size was 3.7 Mbp. Since