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Deletion mapping of the short arm of chromosome 8 in non-small cell lung carcinoma

✍ Scribed by Hiroyuki Ohata; Mitsuru Emi; Yoshiyuki Fujiwara; Kazuya Higashino; Ken Nakagawa; Reiko Futagami; Eiju Tsuchiya; Dr. Yusuke Nakamura

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 309 KB
Volume: 7
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870070204

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✦ Synopsis

Frequent losses of heterozygosity observed at several chromosomal loci in primary lung cancers have indicated the existence of several tumor suppressor genes associated with this type of cancer. We have examined loss of heterozygosity on chromosomal arm 8p in 49 cases of non-small cell lung carcinoma, using I 4 restriction fragment length polymorphism markers. Of 42 cases informative with at least one marker, 2 I showed allelic loss, including I 5 of 32 adenocarcinomas and 5 of 9 squamous cell carcinomas. The frequency of allelic loss on 8p was similar at all clinical stages. Deletion mapping defined a single common region of deletion in these tumors within an 8 cM interval at 8p2I .3-p22 flanked by the loci defined by cMSR-32 and cC18-245. Genes

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