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p53 mutations in cancer

โœ Scribed by Muller, Patricia A. J.; Vousden, Karen H.


Book ID
118173327
Publisher
Nature Publishing Group
Year
2013
Tongue
English
Weight
546 KB
Volume
15
Category
Article
ISSN
1465-7392

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Previous studies have shown that nuclear p53 over-expression is an indicator of p53 mutations whereas cytoplasmic p53 accumulation is related to wild-type p53 in several kinds of tumors. Cytoplasmic p53 accumulation has been demonstrated to be an independent prognostic factor in colorectal adenocarc