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p53 mutation heterogeneity in cancer

โœ Scribed by T. Soussi; G. Lozano


Book ID
116290383
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
177 KB
Volume
331
Category
Article
ISSN
0006-291X

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Previous studies have shown that nuclear p53 over-expression is an indicator of p53 mutations whereas cytoplasmic p53 accumulation is related to wild-type p53 in several kinds of tumors. Cytoplasmic p53 accumulation has been demonstrated to be an independent prognostic factor in colorectal adenocarc