p53 Expression and p53 gene mutation in oral cancer and dysplasia
โ Scribed by Helena Rowley; Paul Sherrington; Timothy R Helliwell; Anne Kinsella; Andrew S. Jones
- Book ID
- 117403466
- Publisher
- SAGE Publications
- Year
- 1998
- Tongue
- English
- Weight
- 249 KB
- Volume
- 118
- Category
- Article
- ISSN
- 0194-5998
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Previous studies of oral cancer have suggested that alterations of the p53 tumour suppressor gene occur early in the precancerous stage of development. However, these observations have been based on cross-sectional assessment of abnormal p53 protein staining by immunohistochemistry and may not neces
To examine the expression of p53 protein and gene alterations in oral epithelial lesions including epithelial dysplasias and primary squamous cell carcinomas, immunohistochemical and temperature gradient gel electrophoresis (TGGE) methods were applied to formalin-fixed and paraffin-embedded tissues.