p53 mutations in betel-associated oral cancer from Thailand
โ Scribed by Paramee Thongsuksai; Pleumjit Boonyaphiphat; Hutcha Sriplung; Wanna Sudhikaran
- Book ID
- 117467924
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 157 KB
- Volume
- 201
- Category
- Article
- ISSN
- 0304-3835
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In this study, we analyzed 53 oral squamous-cell carcinomas among Indians for the presence of alterations in the tumorsuppressor gene p53 by PCR-SSCP and sequencing methods. Our results showed that 21% (I 1/53) of oral carcinomas analyzed carried mutations within the exons 5-8 of the p53 gene. We h
Oral squamous-cell carcinoma (SCC) is the most common neoplasm in Sri Lanka, accounting for approximately 30% of all cancers in males. Epidemiologic evidence indicates that there is an unequivocal relationship between betel chewing and oral carcinogenesis, suggesting that there may be specific genet