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p53 gene mutations in oral carcinomas from India

✍ Scribed by Arasambattu K. Munirajan; Yuko Tutsumi-Ishii; Bagavathi K. C. Mohanprasad; Yasumasa Hirano; Nobuo Munakata; Govindaswamy Shanmugam; Nobuo Tsuchida

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 437 KB
Volume: 66
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19960503)66:3<297::aid-ijc4>3.0.co;2-u

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✦ Synopsis

In this study, we analyzed 53 oral squamous-cell carcinomas among Indians for the presence of alterations in the tumorsuppressor gene p53 by PCR-SSCP and sequencing methods.

Our results showed that 21% (I 1/53) of oral carcinomas analyzed carried mutations within the exons 5-8 of the p53 gene. We have identified I I single-base pair substitutions consisting of 10 mis-sense mutations and one at the splice acceptor site, and one deletion mutation invoMng 4 consecutive bases. The majority of the base substitutions were transitions (5 TA to CG and 5 GC to AT), while only one transversion (TA to GC) was observed. Probable hot-spots for the mutation induction were identified at d o n s 149 and 274, which have not been observed before in head-and-neck cancers. The mutational spectrum might have originated from base alkylations at guanine and thymine residues, caused by some al ating agents.

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