p53 mutant breast cancer patients expressing p53γ have as good a prognosis as wild-type p53 breast cancer patients
✍ Scribed by Jean-Christophe Bourdon; Marie P Khoury; Alexandra Diot; Lee Baker; Kenneth Fernandes; Mustapha Aoubala; Philip Quinlan; Colin A Purdie; Lee B Jordan; Anne-Catherine Prats; David P Lane; Alastair M Thompson
- Book ID
- 118726720
- Publisher
- BioMed Central
- Year
- 2011
- Tongue
- English
- Weight
- 597 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1465-5411
- DOI
- 10.1186/bcr2811
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## Abstract Formalin‐fixed, paraffin‐embedded biopsies of 193 women with primary breast cancer followed‐up for over 10 years were analysed immunohistochemically for the expression of p53 protein. Altogether, 58% (113/193) of the tumors were positive for p53 protein. Over‐expression of p53 was assoc
The prognostic value of p53 protein accumulation in breast cancer, especially as detected by methods other than immunohistochemistry, has not been established unequivocally. A sensitive immunofluorometric assay of p53 protein employing DO-1 and CM-1 antibodies was used in this study to assay extract