p53 As a mutagen test in breast cancer
✍ Scribed by Kathleen A. Hill; Steve S. Sommer
- Publisher
- John Wiley and Sons
- Year
- 2002
- Tongue
- English
- Weight
- 145 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0893-6692
- DOI
- 10.1002/em.10065
No coin nor oath required. For personal study only.
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The prognostic value of p53 protein accumulation in breast cancer, especially as detected by methods other than immunohistochemistry, has not been established unequivocally. A sensitive immunofluorometric assay of p53 protein employing DO-1 and CM-1 antibodies was used in this study to assay extract
## Abstract Overexpression of the nuclear phosphoprotein p53 is one of the most frequently detected abnormalities in human cancer and appears to be associated with mutation of the p53 gene. In this study of breast cancer, p53 overexpression was detected in two (15%) of 15 pure intraductal tumors, 7
## Abstract __p53__‐related genes, __p73__ and __p63__, encode 2 classes of proteins, TA‐p73/p63 and ΔN‐p73/p63. TA‐p73/p63 demonstrate p53‐like properties including gene transactivation and cell death promotion, whereas ΔN‐p73/p63 lack these p53‐like functions. Although p53‐deficient cancer cells
## Abstract Formalin‐fixed, paraffin‐embedded biopsies of 193 women with primary breast cancer followed‐up for over 10 years were analysed immunohistochemically for the expression of p53 protein. Altogether, 58% (113/193) of the tumors were positive for p53 protein. Over‐expression of p53 was assoc